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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-11-8
|
| pubmed:abstractText |
Eleven patients (pts) with advanced refractory breast carcinoma were treated with combination chemotherapy (Planovin) including mitoxantrone 10 mg/m2 on day 1, cisplatin 60 mg/m2 on days 1-2, methotrexate 200 mg/m2 on day 15, vincristine 2 mg on day 15, leucovorin 15 mg/m2 on days 15-16 every 3 weeks. Five patients (41%) achieved an objective response with one complete regression. The median duration of response was 4.5 months and the median duration of survival was 8 months. Drug related toxicity consisted mainly of leukopenia (8 pts), nausea and vomiting (6 pts), anemia (7 pts) and thrombocytopenia (4 pts).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1120-009X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
194-7
|
| pubmed:dateRevised |
2009-8-4
|
| pubmed:meshHeading |
pubmed-meshheading:1919659-Adult,
pubmed-meshheading:1919659-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1919659-Breast Neoplasms,
pubmed-meshheading:1919659-Carcinoma,
pubmed-meshheading:1919659-Cisplatin,
pubmed-meshheading:1919659-Female,
pubmed-meshheading:1919659-Humans,
pubmed-meshheading:1919659-Methotrexate,
pubmed-meshheading:1919659-Middle Aged,
pubmed-meshheading:1919659-Mitoxantrone,
pubmed-meshheading:1919659-Neoplasm Metastasis,
pubmed-meshheading:1919659-Remission Induction,
pubmed-meshheading:1919659-Vincristine
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Intensive chemotherapy with cisplatin, mitoxantrone, methotrexate and vincristine in metastatic breast cancer.
|
| pubmed:affiliation |
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
|
| pubmed:publicationType |
Journal Article
|