Source:http://linkedlifedata.com/resource/pubmed/id/19195885
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2009-2-23
|
| pubmed:abstractText |
The p38 MAP kinase is implicated in the release of the pro-inflammatory cytokines TNFalpha and IL-1b. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A new lead structure for p38 MAP kinase inhibition was identified. Herein, we report the SAR of this new class of p38 inhibitors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1461-4
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:19195885-Binding Sites,
pubmed-meshheading:19195885-Crystallography, X-Ray,
pubmed-meshheading:19195885-Drug Discovery,
pubmed-meshheading:19195885-Humans,
pubmed-meshheading:19195885-Indoles,
pubmed-meshheading:19195885-Protein Kinase Inhibitors,
pubmed-meshheading:19195885-p38 Mitogen-Activated Protein Kinases
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase.
|
| pubmed:affiliation |
Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|