| pubmed-article:1919573 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1919573 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:1919573 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:1919573 | lifeskim:mentions | umls-concept:C0034830 | lld:lifeskim |
| pubmed-article:1919573 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:1919573 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:1919573 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:1919573 | lifeskim:mentions | umls-concept:C0002246 | lld:lifeskim |
| pubmed-article:1919573 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1919573 | pubmed:dateCreated | 1991-11-15 | lld:pubmed |
| pubmed-article:1919573 | pubmed:abstractText | ALS and ARD proteins are thought to represent a ligand binding and a structural subunit, respectively, of Drosophila nicotinic acetylcholine receptors (nAChRs). Here, antibodies raised against fusion constructs encompassing specific regions of the ALS and ARD proteins were used to investigate a potential association of these two polypeptides. Both ALS and ARD antisera removed 20-30% of the high-affinity binding sites for the nicotinic antagonist 125I-alpha-bungarotoxin (125I-alpha-Btx) from detergent extracts of fly head membranes. Combinations of both types of antisera also precipitated the same fraction of alpha-Btx binding sites, a result suggesting that both polypeptides are components of the previously defined class I 125I-alpha-Btx binding sites in the Drosophila CNS. 125I-alpha-Btx binding to a MS2 polymerase-ALS fusion protein containing the predicted antagonist binding region showed that the ALS protein indeed constitutes the ligand binding subunit of a nicotinic receptor complex. These data are consistent with neuronal nAChRs in Drosophila containing at least two types of subunits, ligand binding and structural ones. | lld:pubmed |
| pubmed-article:1919573 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1919573 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1919573 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1919573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1919573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1919573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1919573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1919573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1919573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1919573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1919573 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1919573 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1919573 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:1919573 | pubmed:author | pubmed-author:SchröderCC | lld:pubmed |
| pubmed-article:1919573 | pubmed:author | pubmed-author:BetzHH | lld:pubmed |
| pubmed-article:1919573 | pubmed:author | pubmed-author:SchlossPP | lld:pubmed |
| pubmed-article:1919573 | pubmed:author | pubmed-author:GundelfingerE... | lld:pubmed |
| pubmed-article:1919573 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1919573 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:1919573 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1919573 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1919573 | pubmed:pagination | 1556-62 | lld:pubmed |
| pubmed-article:1919573 | pubmed:dateRevised | 2010-6-4 | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:meshHeading | pubmed-meshheading:1919573-... | lld:pubmed |
| pubmed-article:1919573 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1919573 | pubmed:articleTitle | Neuronal nicotinic acetylcholine receptors in Drosophila: antibodies against an alpha-like and a non-alpha-subunit recognize the same high-affinity alpha-bungarotoxin binding complex. | lld:pubmed |
| pubmed-article:1919573 | pubmed:affiliation | ZMBH, Universität Heidelberg, F.R.G. | lld:pubmed |
| pubmed-article:1919573 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1919573 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:38545 | entrezgene:pubmed | pubmed-article:1919573 | lld:entrezgene |
| entrez-gene:42918 | entrezgene:pubmed | pubmed-article:1919573 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1919573 | lld:pubmed |
