Source:http://linkedlifedata.com/resource/pubmed/id/19195509
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2009-2-6
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pubmed:abstractText |
Drug-eluting stents (DES) have reduced the rate of in-stent restenosis compared with bare-metal stents, but are associated with an increased risk of late stent thrombosis. The proximal left anterior descending artery (LAD) is a large vessel and is considered to be at increased risk of both restenosis and stent thrombosis. The risk-benefit ratio of each type of stent therefore is of great clinical interest in this location. The aim was to compare 1-year outcomes of DESs and bare-metal stents in nonostial proximal LADs. Historic cohorts of patients who underwent percutaneous coronary intervention of nonostial proximal LAD lesions were compared. A total of 137 patients in the bare-metal stent group and 350 patients in the DES group were compared. The primary and secondary end points were target-lesion revascularization (TLR) rate and major adverse cardiac event rate, including death, myocardial infarction and TLR at 1-year follow-up. Patients in both groups had similar baseline characteristics. Intravascular ultrasound guidance was used in most percutaneous coronary intervention (bare-metal stents vs DESs 72.4% vs 74.5%; p = 0.6). Stent diameter was large in both groups (3.2 +/- 0.5 vs 3.2 +/- 0.3 mm; p = 0.6). Patients in the DES group had longer stents implanted (15 +/- 7 vs 17 +/- 7 mm; p <0.01). Major adverse cardiac event and TLR rates were not different (bare-metal stents vs DESs 16.4% vs 14.7%; p = 0.7 and 4.5% vs 5.2%; p = 0.8). In multivariate analysis, the TLR rate was independent of type of stent used. In conclusion, DESs carry no clinical benefit over bare-metal stents for nonostial proximal LAD lesions. Bare-metal stents therefore could be a cost-effective alternative in this location.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1879-1913
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pubmed:author |
pubmed-author:BonelloLaurentL,
pubmed-author:De LabriolleAxelA,
pubmed-author:KaneshigeKimberlyK,
pubmed-author:KentKenneth MKM,
pubmed-author:LemesleGillesG,
pubmed-author:LindsayJosephJ,
pubmed-author:PichardAugusto DAD,
pubmed-author:RoyProbalP,
pubmed-author:SatlerLowell FLF,
pubmed-author:SlottowTina L PintoTL,
pubmed-author:SteinbergDaniel HDH,
pubmed-author:SuddathWilliam OWO,
pubmed-author:TorgusonRebeccaR,
pubmed-author:WaksmanRonR,
pubmed-author:XueZhenyiZ
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
496-500
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19195509-Aged,
pubmed-meshheading:19195509-Angioplasty, Balloon, Coronary,
pubmed-meshheading:19195509-Coronary Artery Disease,
pubmed-meshheading:19195509-Coronary Thrombosis,
pubmed-meshheading:19195509-Coronary Vessels,
pubmed-meshheading:19195509-Drug-Eluting Stents,
pubmed-meshheading:19195509-Female,
pubmed-meshheading:19195509-Humans,
pubmed-meshheading:19195509-Male,
pubmed-meshheading:19195509-Middle Aged,
pubmed-meshheading:19195509-Stents,
pubmed-meshheading:19195509-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
Comparison of outcomes of drug-eluting stents versus bare-metal stents in nonostial proximal left anterior descending coronary arteries.
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pubmed:affiliation |
Department of Internal Medicine, Washington Hospital Center, Washington, DC, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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