Linked Life Data

19193944

Source:http://linkedlifedata.com/resource/pubmed/id/19193944

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-3-27
pubmed:abstractText
Stress is known to be one of the risk factors of stroke, but only a few experimental studies have examined the possible mechanisms by which prior stress may affect stroke outcome. In stroke patients, infections impede neurological recovery and increase morbidity as well as mortality. We previously reported that stress induces a bacterial translocation and that prior immobilization stress worsens experimental stroke outcome through mechanisms that involve inflammatory mediators such as release of proinflammatory cytokines and enzyme activation. We now investigate whether bacterial translocation from the intestinal flora of rats with stress before experimental ischemia is involved in stroke outcome. We used an experimental paradigm consisting of exposure of Fischer rats to repeated immobilization sessions before permanent middle cerebral artery occlusion (MCAO). The presence of bacteria and the levels and expression of different mediators involved in the bacterial translocation were analyzed. Our results indicate that stress before stroke is related to the presence of bacteria in different organs (mesenteric nodes, spleen, liver, and lung) after MCAO and increases inflammatory colonic parameters (such as cyclooxygenase-2, inducible nitric oxide synthase, and myeloperoxidase), but decreases colonic immunoglobulin A, and these results are correlated with colonic inflammation and bacterial translocation. Understanding the implication of bacterial translocation during stress-induced stroke worsening is of great potential clinical relevance, given the high incidence of infections after severe stroke and their main role in mortality and morbidity in stroke patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
296
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R979-85
pubmed:meshHeading
pubmed-meshheading:19193944-Animals, pubmed-meshheading:19193944-Anti-Bacterial Agents, pubmed-meshheading:19193944-Bacterial Translocation, pubmed-meshheading:19193944-Colitis, pubmed-meshheading:19193944-Colon, pubmed-meshheading:19193944-Corticosterone, pubmed-meshheading:19193944-Cyclooxygenase 2, pubmed-meshheading:19193944-Disease Models, Animal, pubmed-meshheading:19193944-Immunoglobulin A, pubmed-meshheading:19193944-Infarction, Middle Cerebral Artery, pubmed-meshheading:19193944-Lung, pubmed-meshheading:19193944-Lymph Nodes, pubmed-meshheading:19193944-Male, pubmed-meshheading:19193944-Nitric Oxide Synthase Type II, pubmed-meshheading:19193944-Penicillin G, pubmed-meshheading:19193944-Permeability, pubmed-meshheading:19193944-Peroxidase, pubmed-meshheading:19193944-Rats, pubmed-meshheading:19193944-Rats, Inbred F344, pubmed-meshheading:19193944-Restraint, Physical, pubmed-meshheading:19193944-Risk Factors, pubmed-meshheading:19193944-Spleen, pubmed-meshheading:19193944-Stress, Psychological, pubmed-meshheading:19193944-Stroke
pubmed:year
2009
pubmed:articleTitle
Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome.
pubmed:affiliation
Department of Pharmacology, Univesity Complutense, 28040 Madrid, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't