rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-6-1
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pubmed:abstractText |
Spontaneous remission of malignant tumors is rare and the biological mechanism of such remission has not been addressed. We report the case of a 71-year-old Japanese patient with non-small cell lung cancer with a right hilar tumor and pleural dissemination that spontaneously regressed. NY-ESO-1 is a cancer/testis antigen that can elicit specific immune responses in patients with cancer. Strong anti-NY-ESO-1 immunity was detected in this patient. His tumor cells expressed NY-ESO-1 and MHC class I molecules. Anti-NY-ESO-1 immunity might have contributed to spontaneous remission in this patient.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CTAG1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/IL2RA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1872-8332
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pubmed:author |
|
pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-22
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pubmed:meshHeading |
pubmed-meshheading:19193472-Aged,
pubmed-meshheading:19193472-Antigens, Neoplasm,
pubmed-meshheading:19193472-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:19193472-Female,
pubmed-meshheading:19193472-Forkhead Transcription Factors,
pubmed-meshheading:19193472-Humans,
pubmed-meshheading:19193472-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:19193472-Lung Neoplasms,
pubmed-meshheading:19193472-Membrane Proteins,
pubmed-meshheading:19193472-Neoplasm Regression, Spontaneous,
pubmed-meshheading:19193472-T-Lymphocytes
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pubmed:year |
2009
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pubmed:articleTitle |
Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity.
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pubmed:affiliation |
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. yi-nakamu@umin.ac.jp
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pubmed:publicationType |
Journal Article,
Case Reports
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