Source:http://linkedlifedata.com/resource/pubmed/id/19193430
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2009-3-24
|
| pubmed:abstractText |
Determinants of endometrial cancer grade have not been precisely defined, however, cell cycle control is considered to be integrally involved in endometrial cancer development. TP53 and MDM2 are essential components for cell cycle arrest and apoptosis. Polymorphisms in these genes cause TP53 inactivation and MDM2 over-expression, leading to accumulation of genetic errors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1095-6859
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
113
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
109-14
|
| pubmed:meshHeading |
pubmed-meshheading:19193430-Case-Control Studies,
pubmed-meshheading:19193430-Endometrial Neoplasms,
pubmed-meshheading:19193430-Female,
pubmed-meshheading:19193430-Genes, p53,
pubmed-meshheading:19193430-Haplotypes,
pubmed-meshheading:19193430-Humans,
pubmed-meshheading:19193430-Neoplasm Staging,
pubmed-meshheading:19193430-Polymorphism, Genetic,
pubmed-meshheading:19193430-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:19193430-Survival Analysis
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer.
|
| pubmed:affiliation |
Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|