Linked Life Data

19193148

Source:http://linkedlifedata.com/resource/pubmed/id/19193148

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-5
pubmed:abstractText
Previous studies have shown that the distribution of genes in prokaryotes and eukaryotic genomes is not random. Using the thousands of cellular functions that appear in the Gene Ontology (GO) project, we exhaustively studied the relation between functionality and genomic localization of genes across 16 organisms with rich GO ontologies (one prokaryote and 15 eukaryotes). Overall, we found that the genomic distribution of cellular functions tends to be more similar in organisms that have higher evolutionary proximity. At the primary level, which measures localization of functionally related genes, the prokaryote Escherichia coli exhibits the highest level of organization, as one would expect given its operon-based genomic organization. However, examining a higher level of genomic organization by analyzing the co-localization of pairs of different functional gene groups, we surprisingly find that the eukaryote yeast Saccharomyces cerevisiae is markedly more organized than E. coli. A network-based analysis further supports this notion and suggests that the eukaryotic genomic architecture is more organized than previously thought. See online Supplementary Material at (www.liebertonline.com).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1557-8666
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-16
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Higher-order genomic organization of cellular functions in yeast.
pubmed:affiliation
School of Computer Sciences, Tel Aviv University, Ramat Aviv, Israel. tamirtul@post.tau.ac.il
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't