19193120

Source:http://linkedlifedata.com/resource/pubmed/id/19193120

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0030956, umls-concept:C0220781, umls-concept:C0439849, umls-concept:C1883254, umls-concept:C2352737, umls-concept:C2607887
pubmed:issue	8
pubmed:dateCreated	2010-6-3
pubmed:abstractText	The peptide isosteres (10 and 11) of the naturally occurring and potent histone deacetylase (HDAC) inhibitors FK228 and largazole have been synthesized and evaluated side-by-side with FK228, largazole, and SAHA for inhibition of the class I HDACs 1, 2, 3, and 6.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/1K08CA128972, http://linkedlifedata.com/resource/pubmed/grant/CA136283, http://linkedlifedata.com/resource/pubmed/grant/GM49631, http://linkedlifedata.com/resource/pubmed/grant/K08 CA128972-01A1
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7503056
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Depsipeptides, http://linkedlifedata.com/resource/pubmed/chemical/HDAC1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase 1, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Lactams, Macrocyclic, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/largazole, http://linkedlifedata.com/resource/pubmed/chemical/romidepsin
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1520-5126
pubmed:author	pubmed-author:BowersAlbert AAA, pubmed-author:BradnerJames EJE, pubmed-author:EstiuGuillerminaG, pubmed-author:GreshockThomas JTJ, pubmed-author:SchreiberStuart LSL, pubmed-author:WestNathanN, pubmed-author:WiestOlafO, pubmed-author:WilliamsRobert MRM
pubmed:issnType	Electronic
pubmed:day	4
pubmed:volume	131
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2900-5
pubmed:dateRevised	2010-12-3
pubmed:meshHeading	pubmed-meshheading:19193120-Catalytic Domain, pubmed-meshheading:19193120-Depsipeptides, pubmed-meshheading:19193120-Histone Deacetylase 1, pubmed-meshheading:19193120-Histone Deacetylase Inhibitors, pubmed-meshheading:19193120-Humans, pubmed-meshheading:19193120-Isomerism, pubmed-meshheading:19193120-Lactams, Macrocyclic, pubmed-meshheading:19193120-Models, Molecular, pubmed-meshheading:19193120-Structure-Activity Relationship, pubmed-meshheading:19193120-Thermodynamics, pubmed-meshheading:19193120-Thiazoles
pubmed:year	2009
pubmed:articleTitle	Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.
pubmed:affiliation	Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural