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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-3-27
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pubmed:abstractText |
Activated hepatic stellate cells (HSCs) are the crucial factor responsible for liver fibrosis and involved in development of hepatocellular carcinoma (HCC) by interaction with tumour cells. Newcastle disease virus (NDV) has the oncolytic characteristics of intrinsically selective replication in neoplasia cells and transformed cells. But, NDV replication in HSCs and effects on hepatic fibrosis have not been reported.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ACTA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1478-3231
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-602
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pubmed:dateRevised |
2011-7-15
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pubmed:meshHeading |
pubmed-meshheading:19192169-Actins,
pubmed-meshheading:19192169-Animals,
pubmed-meshheading:19192169-Apoptosis,
pubmed-meshheading:19192169-Biological Markers,
pubmed-meshheading:19192169-Carcinoma, Hepatocellular,
pubmed-meshheading:19192169-Cell Line, Tumor,
pubmed-meshheading:19192169-Cell Proliferation,
pubmed-meshheading:19192169-Collagen Type I,
pubmed-meshheading:19192169-Culture Media, Conditioned,
pubmed-meshheading:19192169-Cytopathogenic Effect, Viral,
pubmed-meshheading:19192169-Gene Expression Regulation,
pubmed-meshheading:19192169-Hepatic Stellate Cells,
pubmed-meshheading:19192169-Humans,
pubmed-meshheading:19192169-Liver,
pubmed-meshheading:19192169-Liver Cirrhosis, Experimental,
pubmed-meshheading:19192169-Liver Neoplasms,
pubmed-meshheading:19192169-Mice,
pubmed-meshheading:19192169-Newcastle disease virus,
pubmed-meshheading:19192169-Tetrazolium Salts,
pubmed-meshheading:19192169-Thiazoles,
pubmed-meshheading:19192169-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:19192169-Transforming Growth Factor beta1,
pubmed-meshheading:19192169-Virus Replication
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pubmed:year |
2009
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pubmed:articleTitle |
Newcastle disease virus represses the activation of human hepatic stellate cells and reverses the development of hepatic fibrosis in mice.
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pubmed:affiliation |
State Key Laboratory of Cancer Biology, Cell Engineering Research Centre and Department of Cell Biology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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