Source:http://linkedlifedata.com/resource/pubmed/id/19191803
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2010-5-7
|
| pubmed:abstractText |
The clinical significance of C4d positivity in patients with stable graft function is undetermined. This study evaluated the clinical outcome of protocol biopsy-proven C4d-positive renal transplants with stable graft function in the early post-transplantation period. Protocol biopsies (n = 79) were performed on stable allografts on the 14th post-transplant day, and indication biopsies (n = 74) were performed on dysfunctioning allografts within one yr after transplantation. Clinical and histological findings, graft function and graft survival rates were compared between C4d-positive and C4d-negative grafts in each group. The incidence of C4d positivity was 5.1% in protocol biopsies and 9.5% in indication biopsies. In protocol biopsies, C4d-positive allografts showed minimal tubulointerstitial inflammation, and the graft function and graft survival rate did not differ from C4d-negative allografts. All C4d-positive allografts maintained stable graft function without anti-rejection therapy, and follow-up biopsies of two patients showed no C4d deposition or evidence of rejection. On the other hand, C4d-positive allografts in indication biopsies showed severe tissue injury, and the graft survival rate was significantly lower than C4d-negative allografts. In conclusion, C4d-positive allografts with stable graft function in the early post-transplantation period take an indolent course.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1399-0012
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
23
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
812-8
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| pubmed:meshHeading |
pubmed-meshheading:19191803-Adolescent,
pubmed-meshheading:19191803-Adult,
pubmed-meshheading:19191803-Aged,
pubmed-meshheading:19191803-Biopsy,
pubmed-meshheading:19191803-Complement C4b,
pubmed-meshheading:19191803-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19191803-Female,
pubmed-meshheading:19191803-Graft Rejection,
pubmed-meshheading:19191803-Graft Survival,
pubmed-meshheading:19191803-HLA Antigens,
pubmed-meshheading:19191803-Humans,
pubmed-meshheading:19191803-Immunohistochemistry,
pubmed-meshheading:19191803-Incidence,
pubmed-meshheading:19191803-Kidney,
pubmed-meshheading:19191803-Kidney Failure, Chronic,
pubmed-meshheading:19191803-Kidney Transplantation,
pubmed-meshheading:19191803-Male,
pubmed-meshheading:19191803-Middle Aged,
pubmed-meshheading:19191803-Postoperative Period,
pubmed-meshheading:19191803-Prognosis,
pubmed-meshheading:19191803-Retrospective Studies,
pubmed-meshheading:19191803-Transplantation, Homologous,
pubmed-meshheading:19191803-Young Adult
|
| pubmed:articleTitle |
Clinical significance of C4d deposition in stable renal allografts in the early post-transplantation period.
|
| pubmed:affiliation |
Transplantation Research Center, Kangnam St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|