|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001128,
umls-concept:C0011209,
umls-concept:C0017638,
umls-concept:C0018270,
umls-concept:C0026032,
umls-concept:C0027950,
umls-concept:C0205276,
umls-concept:C0332256,
umls-concept:C0522537,
umls-concept:C0524466,
umls-concept:C0939537
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|
pubmed:issue |
4
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|
pubmed:dateCreated |
2009-2-20
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|
pubmed:abstractText |
In an effort to develop new therapeutic strategies to treat malignant gliomas, we have designed poly (lactic-co-glycolic) acid (PLGA) microparticles that deliver imatinib mesylate, a small molecule tyrosine kinase inhibitor. The local continuous release of imatinib mesylate at the tumor site overcomes many obstacles associated with systemic delivery.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1078-0432
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
|
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pubmed:volume |
15
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1222-31
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|
pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19190128-Animals,
pubmed-meshheading:19190128-Brain Neoplasms,
pubmed-meshheading:19190128-Cell Line, Tumor,
pubmed-meshheading:19190128-Cell Survival,
pubmed-meshheading:19190128-Glioma,
pubmed-meshheading:19190128-Humans,
pubmed-meshheading:19190128-Lactic Acid,
pubmed-meshheading:19190128-Male,
pubmed-meshheading:19190128-Mice,
pubmed-meshheading:19190128-Mice, Inbred C57BL,
pubmed-meshheading:19190128-Microspheres,
pubmed-meshheading:19190128-Phosphorylation,
pubmed-meshheading:19190128-Piperazines,
pubmed-meshheading:19190128-Polyglycolic Acid,
pubmed-meshheading:19190128-Pyrimidines,
pubmed-meshheading:19190128-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:19190128-Xenograft Model Antitumor Assays
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|
pubmed:year |
2009
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|
pubmed:articleTitle |
Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth.
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|
pubmed:affiliation |
The Faculty of Biotechnology and Food Engineering, The Technion-Israel Institute of Technology, Haifa, Israel.
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pubmed:publicationType |
Journal Article
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