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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6A
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pubmed:dateCreated |
2009-2-4
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pubmed:abstractText |
GNAS1 encodes the a-subunit of the Gs protein (Gsa), which binds GTP and stimulates adenylyl cyclase. Activating mutations lead to somatotroph, thyroid, adrenal and gonadal adenomas or the McCune-Albright syndrome and recently the T399C polymorphism in GNAS1 has been reported to be associated with malignancies. The purpose of the present case-control study with 349 Japanese prostate cancer patients and 203 urological controls was to determine whether the GNAS1 T393C polymorphism is associated with prostate cancer risk.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3711-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19189654-Adenocarcinoma,
pubmed-meshheading:19189654-Aged,
pubmed-meshheading:19189654-Case-Control Studies,
pubmed-meshheading:19189654-GTP-Binding Protein alpha Subunits, Gs,
pubmed-meshheading:19189654-Genetic Predisposition to Disease,
pubmed-meshheading:19189654-Humans,
pubmed-meshheading:19189654-Male,
pubmed-meshheading:19189654-Polymorphism, Single Nucleotide,
pubmed-meshheading:19189654-Prostatic Hyperplasia,
pubmed-meshheading:19189654-Prostatic Neoplasms
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pubmed:articleTitle |
Lack of involvement of the GNAS1 T393C polymorphism in prostate cancer risk in a Japanese population.
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pubmed:affiliation |
Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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