Linked Life Data

19189108

Source:http://linkedlifedata.com/resource/pubmed/id/19189108

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-5-14
pubmed:abstractText
Lack of adequate sensitivity and spatial resolution in previous noninvasive imaging studies has impeded the depiction of different somatosensory pathways (the medial lemniscus and spinal lemniscus). We investigated whether incorporation of diffusion tensor imaging (DTI) at high isotropic spatial resolution and DTI-based 3D fiber-tractography information can facilitate the study of anatomical parcellation of the somatosensory system in the healthy adult human brainstem. Five healthy men (age range 24-37 years) were studied, and written informed consent was obtained from all subjects. Three-Tesla MRI diffusion tensor tractography (DTT) using fiber assignment by the continuous tracking (FACT) approach at high spatial resolution was used to reconstruct three white matter tracts, the medial lemniscus (ML), spinal lemniscus (SL), and central tegmental tract (CTT), to delineate and quantify the sensory pathways within the brainstem. We demonstrate that these three pathways are distinguishable from each other. The tractographic patterns of the three pathways on all subjects were similar and consistent with atlases of anatomy. We also quantified the diffusion tensor metrics (fractional anisotropy and mean diffusivity) of the two somatosensory pathways, the SL and ML. The fractional anisotropy of the ML was significantly higher than that of the SL (p = 0.005) The average diffusivity was significantly smaller for the ML than for the SL (p = 0.003).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1432-1084
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1480-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Diffusion tensor tractography of the somatosensory system in the human brainstem: initial findings using high isotropic spatial resolution at 3.0 T.
pubmed:affiliation
Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 2.100, Houston, TX 77030, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural