Follicular lymphoma (FL) is the most common subtype of indolent lymphomas. Rituximab is widely used alone or in combination therapy for the treatment of FL. Despite its well-established clinical efficacy, a subpopulation of patients does not respond to rituximab and most patients will relapse after therapy. The mechanisms of action and resistance to rituximab are not fully understood.
Université Claude Bernard de Lyon, Institut National de la Sante et de la Recherche Medicale, U590, Laboratoire de Cytologie Analytique, Faculte de Medecine Rockefeller, Lyon, France. stephane.dalle@chu-lyon.fr