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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0033268,
umls-concept:C0205087,
umls-concept:C0205390,
umls-concept:C0221912,
umls-concept:C0332448,
umls-concept:C0597357,
umls-concept:C0681850,
umls-concept:C0762640,
umls-concept:C0871261,
umls-concept:C1336681,
umls-concept:C1550501,
umls-concept:C1704632,
umls-concept:C1706203,
umls-concept:C1706817,
umls-concept:C2349001,
umls-concept:C2697811,
umls-concept:C2911692
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pubmed:issue |
7
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pubmed:dateCreated |
2009-7-27
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pubmed:abstractText |
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine that triggers dendritic cell-mediated T helper (Th)2 inflammatory responses through a receptor consisting of a heterodimer of the IL-7 receptor alpha (IL-7Ralpha) chain and the TSLP receptor (TSLPR), which resembles the cytokine receptor common gamma chain. Dendritic cells activated by TSLP prime development of CD4(+) T cells into Th2 cells contributing to the pathogenesis of allergic inflammation. We hypothesized that allergen exposure induces expression of TSLP and results in recruitment of TSLPR bearing cells in the cutaneous allergen-induced late-phase reaction (LPR) in atopic subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allergens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/BDCA-1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CLEC4C protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CRLF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/IL7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Inducers,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Poly I-C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-7 receptor, alpha chain,
http://linkedlifedata.com/resource/pubmed/chemical/thymic stromal lymphopoietin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1398-9995
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1014-22
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pubmed:meshHeading |
pubmed-meshheading:19187393-Adolescent,
pubmed-meshheading:19187393-Adult,
pubmed-meshheading:19187393-Allergens,
pubmed-meshheading:19187393-Antigens, Surface,
pubmed-meshheading:19187393-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19187393-Cytokines,
pubmed-meshheading:19187393-Dendritic Cells,
pubmed-meshheading:19187393-Humans,
pubmed-meshheading:19187393-Hypersensitivity,
pubmed-meshheading:19187393-Interferon Inducers,
pubmed-meshheading:19187393-Interleukin-15,
pubmed-meshheading:19187393-Interleukin-7,
pubmed-meshheading:19187393-Lectins, C-Type,
pubmed-meshheading:19187393-Membrane Glycoproteins,
pubmed-meshheading:19187393-Middle Aged,
pubmed-meshheading:19187393-Poly I-C,
pubmed-meshheading:19187393-Receptors, Cytokine,
pubmed-meshheading:19187393-Receptors, Immunologic,
pubmed-meshheading:19187393-Receptors, Interleukin-7,
pubmed-meshheading:19187393-Skin,
pubmed-meshheading:19187393-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen-induced late phase cutaneous responses in atopic subjects.
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pubmed:affiliation |
MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy & Lung Biology, Guy's Hospital, King's College London, London UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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