19187058

Source:http://linkedlifedata.com/resource/pubmed/id/19187058

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006121, umls-concept:C0020179, umls-concept:C0086418, umls-concept:C0162340, umls-concept:C0872237, umls-concept:C1457887, umls-concept:C1552861
pubmed:issue	1
pubmed:dateCreated	2009-2-3
pubmed:abstractText	Recent progress in oculomotor research has enabled new insights into the functional neuroanatomy of the human premotor oculomotor brainstem network. In the present review, we provide an overview of its functional neuroanatomy and summarize the broad range of oculomotor dysfunctions that may occur in Huntington's disease (HD) patients. Although some of these oculomotor symptoms point to an involvement of the premotor oculomotor brainstem network in HD, no systematic analysis of this functional system has yet been performed in brains of HD patients. Therefore, its exact contribution to oculomotor symptoms in HD remains unclear. A possible strategy to clarify this issue is the use of unconventional 100-microm-thick serial tissue sections stained for Nissl substance and lipofuscin pigment (Nissl-pigment stain according to Braak). This technique makes it possible to identify the known nuclei of the premotor oculomotor brainstem network and to study their possible involvement in the neurodegenerative process. Studies applying this morphological approach and using the current knowledge regarding the functional neuroanatomy of this human premotor oculomotor brainstem network will help to elucidate the anatomical basis of the large spectrum of oculomotor dysfunctions that are observed in HD patients. This knowledge may aid clinicians in the diagnosis and monitoring of the disease.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7609829
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1365-2990
pubmed:author	pubmed-author:BruntE RER, pubmed-author:DellerTT, pubmed-author:Den DunnenW F AWF, pubmed-author:GiergaKK, pubmed-author:HeinsenHH, pubmed-author:LandwehrmeyerBB, pubmed-author:RübUU
pubmed:issnType	Electronic
pubmed:volume	35
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4-15
pubmed:meshHeading	pubmed-meshheading:19187058-Brain Stem, pubmed-meshheading:19187058-Eye Movements, pubmed-meshheading:19187058-Frontal Lobe, pubmed-meshheading:19187058-Humans, pubmed-meshheading:19187058-Huntington Disease, pubmed-meshheading:19187058-Neural Pathways, pubmed-meshheading:19187058-Vision, Binocular
pubmed:year	2009
pubmed:articleTitle	The human premotor oculomotor brainstem system - can it help to understand oculomotor symptoms in Huntington's disease?
pubmed:affiliation	Institute of Clinical Neuroanatomy, J. W. Goethe University, Frankfurt/Main, Germany. drueb@gmx.de
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't