Linked Life Data

19186213

Source:http://linkedlifedata.com/resource/pubmed/id/19186213

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-3-30
pubmed:abstractText
Environmental enrichment (EE) has an important role in brain plasticity. Early research has shown that EE increases the response strength of neurons in the auditory cortex, but it remains unknown whether EE can influence the process of spatial localization in the auditory system. In this study, we raised rats in enriched and standard conditions from postnatal day 10 to day 56. By testing behavioral tasks via auditory cues, we have shown that EE improved the number of correct scores, but decreased the reaction time and azimuth deviation in behavioral performance of sound-azimuth discrimination. By in vivo extracellular recording, we have shown that EE enhanced the directional sensitivity of neurons in the primary auditory cortex. For example, EE rats had a smaller spatial receptive field, sharper frequency tuning curve and directional selective curve of auditory neurons compared with normal rats. Our findings indicate that early exposure to EE increases directional sensitivity. These results provide an insight into developmental plasticity in the auditory system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1095-9564
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
366-76
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Environmental enrichment improves behavioral performance and auditory spatial representation of primary auditory cortical neurons in rat.
pubmed:affiliation
School of Life Science, Institute of Cognitive Neuroscience and Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, East China Normal University, Shanghai, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't