Linked Life Data

19185574

Source:http://linkedlifedata.com/resource/pubmed/id/19185574

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-2-23
pubmed:abstractText
Antisense (AS) peptides complementary to the beta-bulge surface loop VQGEESNDK (Boraschi loop) of the cytokine interleukin-1beta (IL-1beta) have been shown to bind IL-1beta at the Boraschi loop position, and to inhibit some of the IL-1beta-mediated biological effects in vitro. Here we show that primary AS peptide FVITFFSLY inhibits IL-1beta-mediated immunostimulation in vivo in a dose-dependent fashion, while inactive on IL-1beta-induced inflammation, an effect that takes place independently of the Boraschi loop. To the best of our knowledge, this is the first time that an AS peptide has been used successfully in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1873-3468
pubmed:author
pubmed:issnType
Electronic
pubmed:day
18
pubmed:volume
583
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
792-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The immunostimulatory effect of IL-1beta in vivo is blocked by antisense peptides complementary to the loop sequence 163-171.
pubmed:affiliation
Laboratory of Cytokines, Unit of Immunobiology, Institute of Biomedical Technologies (ITB), National Research Council (CNR), Area della Ricerca di S. Cataldo, Via G. Moruzzi 1, I-56124 Pisa, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't