19185514

Source:http://linkedlifedata.com/resource/pubmed/id/19185514

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007589, umls-concept:C0019134, umls-concept:C0020792, umls-concept:C0022203, umls-concept:C0678594, umls-concept:C1144383, umls-concept:C1167622, umls-concept:C1337092, umls-concept:C1511938, umls-concept:C1514562, umls-concept:C1547011, umls-concept:C1879746
pubmed:issue	4
pubmed:dateCreated	2009-3-23
pubmed:abstractText	The presence of 3-O-sulfated glucosamine residues in heparin or heparan sulfate plays a role in binding to antithrombin III and HSV infection. In this study, tandem mass spectrometry was used to differentiate between two heparin disaccharide isomers containing variable sulfate at C6 in a common disaccharide and C3 in a more rare one. The dissociation patterns shown by MS(2) and MS(3) were clearly distinguishable between the isomers, allowing their differentiation and quantitation. Using this technique, we show that an octasaccharide with 11 sulfate groups with high affinity for inflammatory chemokine CCL2 does not contain 3-O-sulfated disaccharides.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/GM33063, http://linkedlifedata.com/resource/pubmed/grant/GM47356, http://linkedlifedata.com/resource/pubmed/grant/R01 GM047356-14, http://linkedlifedata.com/resource/pubmed/grant/R01 GM047356-15, http://linkedlifedata.com/resource/pubmed/grant/R37 GM033063-25, http://linkedlifedata.com/resource/pubmed/grant/R37 GM033063-26
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-10520990, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-10521350, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-10608887, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-10783877, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-12137280, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-12571364, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-12765778, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-12964742, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-15033939, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-15843596, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-15922935, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-16033763, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-16099108, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-16735126, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-16940509, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-17460664, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-18376390, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-3706560, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-4037068, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-4084555, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-8347612, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-9737951, http://linkedlifedata.com/resource/pubmed/commentcorrection/19185514-9837883
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9010412
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2, http://linkedlifedata.com/resource/pubmed/chemical/Disaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Glycosaminoglycans, http://linkedlifedata.com/resource/pubmed/chemical/Heparin, http://linkedlifedata.com/resource/pubmed/chemical/Oligosaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Sulfates, http://linkedlifedata.com/resource/pubmed/chemical/heparin disaccharide
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1879-1123
pubmed:author	pubmed-author:EskoJeffrey DJD, pubmed-author:GirardiMatthewM, pubmed-author:LawrenceRogerR, pubmed-author:LearyJulie AJA, pubmed-author:MeissenJohn KJK, pubmed-author:SweeneyMatthew DMD
pubmed:issnType	Electronic
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	652-7
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:19185514-Animals, pubmed-meshheading:19185514-Binding Sites, pubmed-meshheading:19185514-CHO Cells, pubmed-meshheading:19185514-Chemokine CCL2, pubmed-meshheading:19185514-Cricetinae, pubmed-meshheading:19185514-Cricetulus, pubmed-meshheading:19185514-Disaccharides, pubmed-meshheading:19185514-Glycosaminoglycans, pubmed-meshheading:19185514-Heparin, pubmed-meshheading:19185514-Humans, pubmed-meshheading:19185514-Isomerism, pubmed-meshheading:19185514-Oligosaccharides, pubmed-meshheading:19185514-Protein Binding, pubmed-meshheading:19185514-Sulfates, pubmed-meshheading:19185514-Tandem Mass Spectrometry
pubmed:year	2009
pubmed:articleTitle	Differentiation of 3-O-sulfated heparin disaccharide isomers: identification of structural aspects of the heparin CCL2 binding motif.
pubmed:affiliation	Department of Molecular and Cellular Biology, University of California, Davis, California 95616, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural