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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-3-17
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pubmed:abstractText |
Blue makes it happen: The non-uniform charge distribution of the blue colored azulene framework is highly suitable for the bioisosteric replacement of bicyclic heteroarene moieties. Showing an analogous binding mode as heterocyclic dopamine D4 receptor-selective lead compounds, the induction of penile erection in rats over a greater range of doses indicates a putative advantage of the rationally developed azulene derivative 2 b over apomorphine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1860-7187
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-8
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pubmed:meshHeading |
pubmed-meshheading:19185034-Animals,
pubmed-meshheading:19185034-Apomorphine,
pubmed-meshheading:19185034-Azulenes,
pubmed-meshheading:19185034-Drug Design,
pubmed-meshheading:19185034-Humans,
pubmed-meshheading:19185034-Ligands,
pubmed-meshheading:19185034-Male,
pubmed-meshheading:19185034-Penile Erection,
pubmed-meshheading:19185034-Point Mutation,
pubmed-meshheading:19185034-Protein Binding,
pubmed-meshheading:19185034-Rats,
pubmed-meshheading:19185034-Receptors, Dopamine D4
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pubmed:year |
2009
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pubmed:articleTitle |
The azulene framework as a novel arene bioisostere: design of potent dopamine D4 receptor ligands inducing penile erection.
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pubmed:affiliation |
Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich Alexander University, Schuhstrasse 19, 91052 Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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