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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-2-25
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pubmed:abstractText |
We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected]
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1546-1718
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pubmed:author |
pubmed-author:AsmusFriedrichF,
pubmed-author:AuffEduardE,
pubmed-author:BöttcherYvonneY,
pubmed-author:BenedikzJohnJ,
pubmed-author:BjornsdottirGydaG,
pubmed-author:DichgansMartinM,
pubmed-author:GudjonsdottirIris HIH,
pubmed-author:GulcherJeffreyJ,
pubmed-author:GustafssonOmarO,
pubmed-author:HaubenbergerDietrichD,
pubmed-author:HotzyChristophC,
pubmed-author:JakobssonFinnbogiF,
pubmed-author:JonsdottirGudrun AGA,
pubmed-author:JonssonThorlakurT,
pubmed-author:KongAugustineA,
pubmed-author:KristleifssonKristleifurK,
pubmed-author:MiyatakeLisa ALA,
pubmed-author:PalssonStefan TST,
pubmed-author:PeturssonHjorvarH,
pubmed-author:RosenAmi RAR,
pubmed-author:RyeDavidD,
pubmed-author:SaemundsdottirJonaJ,
pubmed-author:SchölsLudgerL,
pubmed-author:StefanssonHreinnH,
pubmed-author:StefanssonKariK,
pubmed-author:SteinbergStacyS,
pubmed-author:TestaClaudia MCM,
pubmed-author:ThorlaciusTheodoraT,
pubmed-author:ThorsteinsdottirUnnurU,
pubmed-author:ZimprichAlexanderA
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-9
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pubmed:dateRevised |
2011-9-22
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pubmed:meshHeading |
pubmed-meshheading:19182806-Animals,
pubmed-meshheading:19182806-Austria,
pubmed-meshheading:19182806-Essential Tremor,
pubmed-meshheading:19182806-Gene Frequency,
pubmed-meshheading:19182806-Genetic Predisposition to Disease,
pubmed-meshheading:19182806-Genetics, Population,
pubmed-meshheading:19182806-Genome-Wide Association Study,
pubmed-meshheading:19182806-Germany,
pubmed-meshheading:19182806-Humans,
pubmed-meshheading:19182806-Iceland,
pubmed-meshheading:19182806-Linkage Disequilibrium,
pubmed-meshheading:19182806-Membrane Proteins,
pubmed-meshheading:19182806-Mice,
pubmed-meshheading:19182806-Mice, Knockout,
pubmed-meshheading:19182806-Nerve Tissue Proteins,
pubmed-meshheading:19182806-Polymorphism, Single Nucleotide,
pubmed-meshheading:19182806-Risk Factors,
pubmed-meshheading:19182806-United States
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pubmed:year |
2009
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pubmed:articleTitle |
Variant in the sequence of the LINGO1 gene confers risk of essential tremor.
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pubmed:affiliation |
deCODE genetics, Sturlugata 8, IS-101 Reykjavík, Iceland.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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