Linked Life Data

19182473

Source:http://linkedlifedata.com/resource/pubmed/id/19182473

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-2-2
pubmed:abstractText
Frontotemporal dementia (FTD) is characterized by different severity of frontotemporal atrophy, and histologically by neuronal loss, gliosis and spongiosis. Due to the new discoveries in biochemistry,genetics and neuropathology, re-examination of the former neuropathological criteria was necessary.Actually, we distinguish subgroups on the basis of the presence or absence of intraneuronal or intraneuronal and glial inclusions: the so-called FTD tauopathies, such as Pick's disease, corticobasal degeneration, progressive supranuclear palsy, FTD with parkinsonism linked to chromosome 17,argyrophilic grain disease and neurofibrillary tangle dementia. FTD nontauopathies include dementia lacking distinctive histology (without any known inclusion) and FTD (clinically with or without motor neuron disease) with ubiquitin-immunoreactive inclusions. In the latter group, a new pathological protein, the TAR-binding protein (TDP-43), was recently described as the main component of inclusion, and several new mutations were also discovered. The new neuropathological criteria could be a great help in the neuropathological diagnosis and in further clinicopathological studies, and the new discoveries are useful in understanding the underlying disease processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1660-4431
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2009 S. Karger AG, Basel.
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-59
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Neuropathological spectrum of frontal lobe dementias.
pubmed:affiliation
Division of Neuropsychiatry, Department of Psychiatry, Geneva School of Medicine, Chêne-Bourg, Geneva, Switzerland. eniko.kovari@hcuge.ch
pubmed:publicationType
Journal Article, Review