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| pubmed-article:19182202 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:19182202 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:19182202 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:19182202 | lifeskim:mentions | umls-concept:C0024314 | lld:lifeskim |
| pubmed-article:19182202 | lifeskim:mentions | umls-concept:C0026470 | lld:lifeskim |
| pubmed-article:19182202 | lifeskim:mentions | umls-concept:C0032112 | lld:lifeskim |
| pubmed-article:19182202 | lifeskim:mentions | umls-concept:C0038995 | lld:lifeskim |
| pubmed-article:19182202 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19182202 | pubmed:dateCreated | 2009-7-24 | lld:pubmed |
| pubmed-article:19182202 | pubmed:abstractText | Familial clustering of the precursor condition, monoclonal gammopathy of undetermined significance (MGUS) has been observed in case reports and in smaller studies. Using population-based data from Sweden, we identified 4458 MGUS patients, 17505 population-based controls, and first-degree relatives of patients (n = 14621) and controls (n = 58387) with the aim to assess risk of MGUS and lymphoproliferative malignancies among first-degree relatives of MGUS patients. Compared with relatives of controls, relatives of MGUS patients had increased risk of MGUS (relative risk [RR] = 2.8; 1.4-5.6), multiple myeloma (MM; RR = 2.9; 1.9-4.3), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM; RR = 4.0; 1.5-11), and chronic lymphocytic leukemia (CLL; RR = 2.0; 1.2-2.3). Relatives of patients with IgG/IgA MGUS had a 4.0-fold (1.7-9.2), 2.9-fold (1.7-4.9), and 20-fold (2.3-170) elevated risk of developing MGUS, MM, and LPL/WM, respectively. Relatives of IgM MGUS patients had 5.0-fold (1.1-23) increased CLL risk and nonsignificant excess MM and LPL/WM risks. The results were very similar when we assessed risk by type of first-degree relative, age at MGUS (above/below 65 years), or sex. Risk of non-Hodgkin lymphoma or Hodgkin lymphoma was not increased among MGUS relatives. Among first-degree relatives of a nationwide MGUS cohort, we found elevated risks of MGUS, MM, LPL/WM, and CLL, supporting a role for germline susceptibility genes, shared environmental influences, or an interaction between both. | lld:pubmed |
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| pubmed-article:19182202 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19182202 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19182202 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19182202 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19182202 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19182202 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:19182202 | pubmed:author | pubmed-author:WahlinAndersA | lld:pubmed |
| pubmed-article:19182202 | pubmed:author | pubmed-author:LandgrenOlaO | lld:pubmed |
| pubmed-article:19182202 | pubmed:author | pubmed-author:GoldinLynn... | lld:pubmed |
| pubmed-article:19182202 | pubmed:author | pubmed-author:CaporasoNeil... | lld:pubmed |
| pubmed-article:19182202 | pubmed:author | pubmed-author:TuressonIngem... | lld:pubmed |
| pubmed-article:19182202 | pubmed:author | pubmed-author:MellqvistUlf-... | lld:pubmed |
| pubmed-article:19182202 | pubmed:author | pubmed-author:BjorkholmMagn... | lld:pubmed |
| pubmed-article:19182202 | pubmed:author | pubmed-author:BlimarkCecili... | lld:pubmed |
| pubmed-article:19182202 | pubmed:author | pubmed-author:KristinssonSi... | lld:pubmed |
| pubmed-article:19182202 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19182202 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:19182202 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:19182202 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19182202 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19182202 | pubmed:pagination | 791-5 | lld:pubmed |
| pubmed-article:19182202 | pubmed:dateRevised | 2010-9-22 | lld:pubmed |
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| pubmed-article:19182202 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19182202 | pubmed:articleTitle | Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden. | lld:pubmed |
| pubmed-article:19182202 | pubmed:affiliation | Division of Cancer Epidemiology and Genetics, and Center for Cancer Research, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. landgreo@mail.nih.gov | lld:pubmed |
| pubmed-article:19182202 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19182202 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19182202 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:19182202 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:19182202 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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