Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-7-24
pubmed:abstractText
Familial clustering of the precursor condition, monoclonal gammopathy of undetermined significance (MGUS) has been observed in case reports and in smaller studies. Using population-based data from Sweden, we identified 4458 MGUS patients, 17505 population-based controls, and first-degree relatives of patients (n = 14621) and controls (n = 58387) with the aim to assess risk of MGUS and lymphoproliferative malignancies among first-degree relatives of MGUS patients. Compared with relatives of controls, relatives of MGUS patients had increased risk of MGUS (relative risk [RR] = 2.8; 1.4-5.6), multiple myeloma (MM; RR = 2.9; 1.9-4.3), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM; RR = 4.0; 1.5-11), and chronic lymphocytic leukemia (CLL; RR = 2.0; 1.2-2.3). Relatives of patients with IgG/IgA MGUS had a 4.0-fold (1.7-9.2), 2.9-fold (1.7-4.9), and 20-fold (2.3-170) elevated risk of developing MGUS, MM, and LPL/WM, respectively. Relatives of IgM MGUS patients had 5.0-fold (1.1-23) increased CLL risk and nonsignificant excess MM and LPL/WM risks. The results were very similar when we assessed risk by type of first-degree relative, age at MGUS (above/below 65 years), or sex. Risk of non-Hodgkin lymphoma or Hodgkin lymphoma was not increased among MGUS relatives. Among first-degree relatives of a nationwide MGUS cohort, we found elevated risks of MGUS, MM, LPL/WM, and CLL, supporting a role for germline susceptibility genes, shared environmental influences, or an interaction between both.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-11584064, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-12351413, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-12780789, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-12881316, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-15112271, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-15469426, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-15642671, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-15681516, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-16210333, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-16304401, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-16391371, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-16395700, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-16571879, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-17488966, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-17583571, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-1761205, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-18021086, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-18053453, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-18239085, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-18614782, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-18703425, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-18809818, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-19628711, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-2110928, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-3103417, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-4160039, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-645746, http://linkedlifedata.com/resource/pubmed/commentcorrection/19182202-8299769
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
23
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
791-5
pubmed:dateRevised
2010-9-22
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden.
pubmed:affiliation
Division of Cancer Epidemiology and Genetics, and Center for Cancer Research, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. landgreo@mail.nih.gov
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural