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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1977-5-20
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pubmed:abstractText |
A transplantable insulinoma was developed in inbred albino rats of the NEDH strain. The original tumor, 1 cm in diameter, was removed from the pancreas of a male parabiont 566 days folowing 1000 rads (10J/kg) of total body x-irradiation. The time required for implanted fragments to grow to 0.5-1.5 cm in diameter decreased from 5-8 months in the first generation to 2-5 months in the seventh generation. Successful transplantation in male animals followed for 4 or more months after transplantation was significantly greater than in female animals followed for a similar period of time (96% versus 69%). Light and electron microscopy revealed that the tumors consisted predominantly of well-granulated beta cells. Ultrastructural studies also showed small numbers of D-cells. Tumor extracts contained an average of 223 units of immunoreactive insulin and 25.9 mug of immunoreactive somato-statin per gram wet weight of tissue. Tumors generally produced increasingly profound hypoglycemia within 2-4 months following transplantation, with plasma glucose levels frequently falling to 40 mg/100 ml or lower prior to death. Removal of tumors from chronically hypoglycemic animals resulted in transient rebound hyperglycemia with plasma glucose levels above 300mg/100 ml within the first 24 hr and a gradual decline to normal levels of 129 mg/100ml in 2-4 days. These observations correlated with findings of marked atropy and degranulation of the beta cells in the pancreata of tumor-bearing animals, and with gradual return of normal light microscopic morphology following tumor removal.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-1213648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-14146168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-14166605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-14493916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-180543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-185618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4123145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4127645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4201956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4286709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4306600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4313182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4318337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4325738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4326174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4365139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4559917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-4564778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-5228586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-5850216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/191819-773728
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
628-32
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:191819-Adenoma, Islet Cell,
pubmed-meshheading:191819-Animals,
pubmed-meshheading:191819-Blood Glucose,
pubmed-meshheading:191819-Insulin,
pubmed-meshheading:191819-Islets of Langerhans,
pubmed-meshheading:191819-Male,
pubmed-meshheading:191819-Microscopy, Electron,
pubmed-meshheading:191819-Neoplasm Transplantation,
pubmed-meshheading:191819-Neoplasms, Experimental,
pubmed-meshheading:191819-Rats
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pubmed:year |
1977
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pubmed:articleTitle |
A transplantable insulinoma in the rat.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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