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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-11-30
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pubmed:abstractText |
Our previous study showed that 17beta-estradiol (E2) and an adenosine A(2A) receptor (AR-A(2A)) agonist could attenuate subarachnoid hemorrhage (SAH)-induced cerebral vasospasm via preventing the augmentation of iNOS expression and preserving the normal eNOS expression. This study tests the hypothesis that E2 attenuates SAH-induced vasospasm and apoptosis by activating adenosine AR-A(2A) and extracellular signal-regulated kinase 1 and 2 (ERK1/2), and by altering antiapoptotic and proapoptotic protein expression (Bcl-2 and Bax, respectively).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Adenosine A2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/fulvestrant
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1095-8673
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
208-15
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pubmed:meshHeading |
pubmed-meshheading:19181336-Animals,
pubmed-meshheading:19181336-Apoptosis,
pubmed-meshheading:19181336-Dentate Gyrus,
pubmed-meshheading:19181336-Estradiol,
pubmed-meshheading:19181336-Estrogens,
pubmed-meshheading:19181336-Male,
pubmed-meshheading:19181336-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:19181336-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:19181336-Models, Animal,
pubmed-meshheading:19181336-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:19181336-Rats,
pubmed-meshheading:19181336-Rats, Sprague-Dawley,
pubmed-meshheading:19181336-Receptor, Adenosine A2A,
pubmed-meshheading:19181336-Receptors, Estrogen,
pubmed-meshheading:19181336-Subarachnoid Hemorrhage,
pubmed-meshheading:19181336-Vasospasm, Intracranial,
pubmed-meshheading:19181336-bcl-2-Associated X Protein
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pubmed:year |
2009
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pubmed:articleTitle |
17Beta-estradiol activates adenosine A(2a) receptor after subarachnoid hemorrhage.
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pubmed:affiliation |
Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. chihlung1@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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