Linked Life Data

19180557

Source:http://linkedlifedata.com/resource/pubmed/id/19180557

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-8-27
pubmed:abstractText
The default-mode network (DMN) consists of areas showing more activation during rest than during a task. Several authors propose some form of cognitive processing to underlie BOLD signal changes in the DMN as activity within the network is modulated by the level of effort required by the task and is positively correlated with self-referential processing. Alternatively, BOLD signal changes within the DMN may be caused by cardiorespiratory processes (CR) affecting BOLD signal measurements independent of neuronal activity. The goal of this study is to investigate whether BOLD signal changes within the DMN can be explained by CR effects. To this aim, brain activity, heartbeat, and respiration are measured during resting-state and while subjects perform a cognitive task with a high- and low-demand condition. To correct for CR effects we used RETROICOR (Glover et al., [2000]: Magn Reson Med 44:162-167) in combination with additive linear modeling of changes due to respiration volume, heart rate and heart rate variability. CR effects were present within the frequency-range of the DMN and were located in areas of the DMN, but equally so in other areas. After removal of CR effects, deactivation and resting-state connectivity between the areas of the DMN remained significant. In addition, DMN deactivation was still modulated by task demand. The same CR correction method did remove activation in task-related areas. We take these results to indicate that the BOLD signal within the DMN cannot be explained by CR effects alone and is possibly related to some form of cognitive neuronal processing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1097-0193
pubmed:author
pubmed:copyrightInfo
2009 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3031-42
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Cardiorespiratory effects on default-mode network activity as measured with fMRI.
pubmed:affiliation
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. m.vanbuuren-2@umcutrecht.nl
pubmed:publicationType
Journal Article