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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
28
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pubmed:dateCreated |
1991-11-8
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pubmed:databankReference |
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pubmed:abstractText |
The Saccharomyces cerevisiae RNA polymerase II subunit gene RPB9 was isolated and sequenced. RPB9 is a single copy gene on chromosome VII. The RPB9 sequence predicts a protein of 122 amino acids with a molecular mass of 14,200 Da. The yeast RPB9 subunit is similar in size and sequence to a protein encoded by DNA adjacent to the suppressor of the Hairy Wing gene in Drosophila melanogaster. Deletion of the RPB9 gene produced cells that were heat- and cold-sensitive. The RPB9 subunit, like the previously described RNA polymerase II subunit RPB4, is not essential for synthesis of mRNA, but is required for normal cell growth over a wide temperature range.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
266
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pubmed:geneSymbol |
RPB9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19053-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1918023-Amino Acid Sequence,
pubmed-meshheading:1918023-Base Sequence,
pubmed-meshheading:1918023-Blotting, Southern,
pubmed-meshheading:1918023-Chromosome Mapping,
pubmed-meshheading:1918023-DNA, Fungal,
pubmed-meshheading:1918023-Genes, Fungal,
pubmed-meshheading:1918023-Molecular Sequence Data,
pubmed-meshheading:1918023-RNA Polymerase II,
pubmed-meshheading:1918023-Saccharomyces cerevisiae,
pubmed-meshheading:1918023-Sequence Alignment,
pubmed-meshheading:1918023-Temperature
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pubmed:year |
1991
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pubmed:articleTitle |
Yeast RNA polymerase II subunit RPB9 is essential for growth at temperature extremes.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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