|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2009-2-19
|
|
pubmed:abstractText |
Two important goals in stem cell research are to control the cell proliferation without differentiation and to direct the differentiation into a specific cell lineage when desired. Here, we demonstrate such paths by controlling only the nanotopography of culture substrates. Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media. hMSC behavior in response to defined nanotube sizes revealed a very dramatic change in hMSC behavior in a relatively narrow range of nanotube dimensions. Small (approximately 30-nm diameter) nanotubes promoted adhesion without noticeable differentiation, whereas larger (approximately 70- to 100-nm diameter) nanotubes elicited a dramatic stem cell elongation (approximately 10-fold increased), which induced cytoskeletal stress and selective differentiation into osteoblast-like cells, offering a promising nanotechnology-based route for unique orthopedics-related hMSC treatments.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-10102814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-10905463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-11451046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-11772952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-14202300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-14598441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-15068789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-15769528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-16114950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-16373694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-16443268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-16602089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-16804024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-16913737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-16923388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-16963119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-17089417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-17212442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-17335895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-17450779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-17455983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-17503870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-17891143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-17958387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-18055443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-18186610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-18251515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-18287082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-18468059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-18703661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-19506261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19179282-7961716
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1091-6490
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
17
|
|
pubmed:volume |
106
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2130-5
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:19179282-Cell Adhesion,
pubmed-meshheading:19179282-Cell Differentiation,
pubmed-meshheading:19179282-Cell Lineage,
pubmed-meshheading:19179282-Cell Proliferation,
pubmed-meshheading:19179282-Humans,
pubmed-meshheading:19179282-Immune System,
pubmed-meshheading:19179282-Mesenchymal Stem Cells,
pubmed-meshheading:19179282-Metal Nanoparticles,
pubmed-meshheading:19179282-Microscopy, Electron, Scanning,
pubmed-meshheading:19179282-Microscopy, Fluorescence,
pubmed-meshheading:19179282-Nanotechnology,
pubmed-meshheading:19179282-Nanotubes,
pubmed-meshheading:19179282-Osteoblasts,
pubmed-meshheading:19179282-Stem Cells,
pubmed-meshheading:19179282-Titanium
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Stem cell fate dictated solely by altered nanotube dimension.
|
|
pubmed:affiliation |
Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
