Source:http://linkedlifedata.com/resource/pubmed/id/19179077
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2009-2-23
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pubmed:abstractText |
In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1481-3
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pubmed:meshHeading |
pubmed-meshheading:19179077-Animals,
pubmed-meshheading:19179077-Basilar Artery,
pubmed-meshheading:19179077-Curcumin,
pubmed-meshheading:19179077-Dose-Response Relationship, Drug,
pubmed-meshheading:19179077-Male,
pubmed-meshheading:19179077-Molecular Mimicry,
pubmed-meshheading:19179077-Rabbits,
pubmed-meshheading:19179077-Sulfinic Acids,
pubmed-meshheading:19179077-Vasodilation,
pubmed-meshheading:19179077-Vasodilator Agents
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits.
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pubmed:affiliation |
Department of Basic Sciences and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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