Source:http://linkedlifedata.com/resource/pubmed/id/19178961
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-12-14
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| pubmed:abstractText |
The recent introduction of drug-eluting stents in angioplasty of atherosclerotic blood vessels has significantly reduced the risks of in-stent restenosis (ISR) [1]. Indeed, it is known that in conventional stents ISR takes place in over 20% of the cases and up to 60% when implanted in diabetic patients. Conversely, clinical trials have shown that drug-eluting stents have significantly reduced ISR. Among the drug-eluting stents available on the market, Taxus stents (Tax, Boston Scientific, USA) are among the most used devices [2]. Tax are stainless-steel stents coated with Translute, a poly(styrene-b-isobutylene-b-styrene) polymer (PSIBS) eluting Placlitaxel, an anti-mitotic drug. Clinical trials on this type of drug-eluting stents have shown an incidence of restenosis of approximately 4%. The majority of these trials were randomized studies where conventional stents and drug-eluting devices have been implanted in separate patients' cohorts. Such a randomized design, although fundamental to collect statistically-relevant data, does not allow a direct histological comparison of different stent types when implanted in the same patient and do not show the individual susceptibility to the host response especially at short-term implantation times. Here, an interesting case study is presented where two chrome-cobalt stents (Z Guidant, ZG, Guidant Corp.) and a Tax have been simultaneously implanted in the same patient in three separate coronary arteries, retrieved after only 8 weeks and histologically analysed.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1874-1754
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
3
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| pubmed:volume |
145
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
e83-5
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| pubmed:meshHeading |
pubmed-meshheading:19178961-Angioplasty,
pubmed-meshheading:19178961-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:19178961-Chromium Alloys,
pubmed-meshheading:19178961-Coronary Artery Disease,
pubmed-meshheading:19178961-Coronary Restenosis,
pubmed-meshheading:19178961-Drug-Eluting Stents,
pubmed-meshheading:19178961-Humans,
pubmed-meshheading:19178961-Paclitaxel
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| pubmed:year |
2010
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| pubmed:articleTitle |
Direct comparison of the short-term clinical performance of Z Guidant and Taxus stents.
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| pubmed:publicationType |
Letter
|