Source:http://linkedlifedata.com/resource/pubmed/id/19178941
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2009-3-2
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| pubmed:abstractText |
A poly(organophosphazene)-PTX conjugate was synthesized by a covalent ester linkage between PTX and carboxylic acid-terminated poly(organophosphazene), which can be readily modified by various hydrophobic, hydrophilic, and other functional substitutes. The physicochemical properties, hydrolytic degradation and PTX release behaviors of the polymer-PTX conjugate were characterized, in addition to the in vitro and in vivo antitumor activities. The aqueous solutions of these conjugates showed a sol-gel transition behavior that depended on temperature changes. The in vitro antitumor activity of the polymer-PTX conjugate was investigated by an MTT assay against human tumor cell lines. From the in vivo antitumor activity studies with tumor-induced (xenografted) nude mice, the polymer-paclitaxel conjugate hydrogels after local injection at the tumor site were shown to inhibit tumor growth more effectively and longer than paclitaxel and saline alone, indicating that the tumor-active paclitaxel from the polymer-PTX conjugate hydrogel is released slowly over a longer period of time and effectively accumulated locally in the tumor sites. These combined observations suggest that this poly(organophosphazene)-PTX conjugate holds promise for use in clinical studies as single and/or combination therapies.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Gels,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Water,
http://linkedlifedata.com/resource/pubmed/chemical/poly(organophosphazene)
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1878-5905
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
30
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2349-60
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| pubmed:meshHeading |
pubmed-meshheading:19178941-Animals,
pubmed-meshheading:19178941-Antineoplastic Agents,
pubmed-meshheading:19178941-Cell Line, Tumor,
pubmed-meshheading:19178941-Cell Survival,
pubmed-meshheading:19178941-Female,
pubmed-meshheading:19178941-Gels,
pubmed-meshheading:19178941-Humans,
pubmed-meshheading:19178941-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19178941-Mice,
pubmed-meshheading:19178941-Mice, Inbred BALB C,
pubmed-meshheading:19178941-Mice, Nude,
pubmed-meshheading:19178941-Molecular Structure,
pubmed-meshheading:19178941-Organophosphorus Compounds,
pubmed-meshheading:19178941-Paclitaxel,
pubmed-meshheading:19178941-Phase Transition,
pubmed-meshheading:19178941-Polymers,
pubmed-meshheading:19178941-Positron-Emission Tomography,
pubmed-meshheading:19178941-Sensitivity and Specificity,
pubmed-meshheading:19178941-Temperature,
pubmed-meshheading:19178941-Water,
pubmed-meshheading:19178941-Xenograft Model Antitumor Assays
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Thermosensitive poly(organophosphazene)-paclitaxel conjugate gels for antitumor applications.
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| pubmed:affiliation |
Division of Life Science, Korea Institute of Science and Technology, Cheongryang, Seoul 136-791, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|