Source:http://linkedlifedata.com/resource/pubmed/id/19178787
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-1-30
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| pubmed:abstractText |
Using the Bayley test, the mental and psychomotor development in a cohort of 253 children were evaluated. Maternal dietary intake of vitamin B(12) and folate was assessed from a semiquantitative questionnaire administered during the first trimester of pregnancy. Maternal genotypes of MTHFR (677C>T and 1298A>C), were ascertained by PCR-RFLP. The 677T and 1298C variant alleles were present in 59% and 10% of participants, respectively. A dietary deficiency of vitamin B(12) was negatively associated with mental development (beta = -1.6; 95% CI = -2.8 to -0.3). In contrast, dietary intake of folate (< 400 mg/day) reduced the mental development index only among children of mothers who were carriers of the TT genotype (beta = -1.8; 95% CI = -3.6 to -0.04; P for interaction = 0.07). Vitamin B(12) and folate supplementation during pregnancy could have a favorable impact on the mental development of children during their first year of life, mainly in populations that are genetically susceptible.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1476-8305
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
12
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
13-20
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| pubmed:meshHeading |
pubmed-meshheading:19178787-Adolescent,
pubmed-meshheading:19178787-Adult,
pubmed-meshheading:19178787-Brain,
pubmed-meshheading:19178787-Child Development,
pubmed-meshheading:19178787-Cohort Studies,
pubmed-meshheading:19178787-Diet,
pubmed-meshheading:19178787-Environment,
pubmed-meshheading:19178787-Female,
pubmed-meshheading:19178787-Folic Acid,
pubmed-meshheading:19178787-Folic Acid Deficiency,
pubmed-meshheading:19178787-Genotype,
pubmed-meshheading:19178787-Humans,
pubmed-meshheading:19178787-Infant,
pubmed-meshheading:19178787-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:19178787-Polymerase Chain Reaction,
pubmed-meshheading:19178787-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:19178787-Pregnancy,
pubmed-meshheading:19178787-Pregnancy Complications,
pubmed-meshheading:19178787-Prenatal Exposure Delayed Effects,
pubmed-meshheading:19178787-Psychomotor Disorders,
pubmed-meshheading:19178787-Vitamin B 12,
pubmed-meshheading:19178787-Vitamin B 12 Deficiency
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| pubmed:year |
2009
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| pubmed:articleTitle |
Maternal MTHFR 677C>T genotype and dietary intake of folate and vitamin B(12): their impact on child neurodevelopment.
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| pubmed:affiliation |
Instituto Nacional de Salud Pública, Morelos, Mexico.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|