Source:http://linkedlifedata.com/resource/pubmed/id/19178561
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2009-4-23
|
| pubmed:abstractText |
Approximately one-third of patients with epilepsy patients have recurrent seizures despite therapy. It has been suggested that therapeutic failure is associated with high expression of the multidrug efflux ABCB1 (MDR1) drug-transporter; specifically, that patients with the 3435CC genotype have higher efflux of anticonvulsants out of brain tissue, with correspondingly lower concentrations in the central nervous system.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1528-1167
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
50
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
898-903
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| pubmed:meshHeading |
pubmed-meshheading:19178561-Anticonvulsants,
pubmed-meshheading:19178561-Case-Control Studies,
pubmed-meshheading:19178561-Confidence Intervals,
pubmed-meshheading:19178561-Cross-Cultural Comparison,
pubmed-meshheading:19178561-Databases, Factual,
pubmed-meshheading:19178561-Drug Resistance,
pubmed-meshheading:19178561-Epilepsy,
pubmed-meshheading:19178561-Humans,
pubmed-meshheading:19178561-P-Glycoprotein,
pubmed-meshheading:19178561-Polymorphism, Single Nucleotide,
pubmed-meshheading:19178561-Retrospective Studies
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis.
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| pubmed:affiliation |
Divisions of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article,
Meta-Analysis
|