Linked Life Data

19177751

Source:http://linkedlifedata.com/resource/pubmed/id/19177751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-30
pubmed:abstractText
The advent of highly active antiretroviral therapy has greatly improved the prognosis of HIV-1 infection, but eradication of the virus has not been achieved. The emergence of antiretroviral-resistant viruses is one of the most important factors affecting the prognosis of HIV-1 infected patients today. In this manuscript, recent progresses in drug resistance HIV researches are reviewed. As for the acquisition of nucleoside analogue RT inhibitor resistance, excision mechanism is more clear by enzymological and structural view points. Recently developed integrase inhibitor, the whole new target of antiretroviral, induces drug resistance mutations in the active sites of integrase. The first drug that targets the host factors, chemokine receptor CCR5, demonstrates different resistance profiles from the present antiretrovirals. These new findings are important to develop successful treatments that will not fail due to drug resistance acquisition.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-51
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Molecular mehanisms of drug resistance acquisition in HIV].
pubmed:affiliation
Department of Infection and Immunology, Clinical Reseach Center, National Hospital Organization, Nagoya Medical Center.
pubmed:publicationType
Journal Article, English Abstract, Review