Linked Life Data

19175672

Source:http://linkedlifedata.com/resource/pubmed/id/19175672

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-3-2
pubmed:abstractText
We discuss mechanisms that enable the scaling of pattern with size during the development of multicellular organisms. Recently, we analyzed scaling in the context of the early Xenopus embryo, focusing on the determination of the dorsal-ventral axis by a gradient of BMP activation. The ability of this system to withstand extreme perturbation was exemplified in classical experiments performed by Hans Spemann in the early 20th century. Quantitative analysis revealed that patterning is governed by a noncanonical 'shuttling-based' mechanism, and defined the feedback enabling the scaling of pattern with size. Robust scaling is due to molecular implementation of an integral-feedback controller, which adjusts the width of the BMP morphogen gradient with the size of the system. We present an 'expansion-repression' feedback topology which generalizes this concept for a wider range of patterning systems, providing a general, and potentially widely applicable model for the robust scaling of morphogen gradients with size.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1742-4658
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
276
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1196-207
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
'Big frog, small frog'--maintaining proportions in embryonic development: delivered on 2 July 2008 at the 33rd FEBS Congress in Athens, Greece.
pubmed:affiliation
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. naama.barkai@weizmann.ac.il
pubmed:publicationType
Lectures