Linked Life Data

19174170

Source:http://linkedlifedata.com/resource/pubmed/id/19174170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-3-9
pubmed:abstractText
In vertebrate somitogenesis, "segmentation clock" genes (such as her in zebrafish, hairy in chick, and hes in mouse) show oscillation, synchronized over nearby cells through cell-cell interaction. The locations of high gene expression appear with regular intervals and move like a wave from posterior to anterior with the speed slowing down toward the anterior end. We analyze traveling wave pattern of her gene expression when there is an anterior-posterior gradient of one of the reaction rates in the gene-protein kinetics. We adopt a model which includes the kinetics of mRNA and proteins of her gene in each cell and cell-cell interaction by Delta-Notch system explicitly. We show that the observed spatio-temporal pattern can be explained if mRNA degradation, protein translation, protein transportation to nucleus occurs faster, or mRNA transcription, Delta protein synthesis occurs slower in posterior than in anterior regions. All of these gradients are those that produce longer periodicity of oscillation of clock gene expression in the anterior than in the posterior. Based on this result, we derive a mathematical formula for how the peak of gene expression moves along the pre-somitic mesoderm.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1095-8541
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
257
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
385-96
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Traveling wave formation in vertebrate segmentation.
pubmed:affiliation
Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan. uriu@bio-math10.biology.kyushu-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't