Linked Life Data

19172693

Source:http://linkedlifedata.com/resource/pubmed/id/19172693

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-1-26
pubmed:abstractText
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues. They can differentiate into cells of the mesodermal lineage, such as adipocytes, osteocytes and chondrocytes, as well as cells of other embryonic lineages. MSCs can interact with cells of both the innate and adaptive immune systems, leading to the modulation of several effector functions. After in vivo administration, MSCs induce peripheral tolerance and migrate to injured tissues, where they can inhibit the release of pro-inflammatory cytokines and promote the survival of damaged cells. This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1474-1733
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
726-36
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Mesenchymal stem cells in health and disease.
pubmed:affiliation
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy. auccelli@neurologia.unige.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't