19171969

Source:http://linkedlifedata.com/resource/pubmed/id/19171969

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0678594, umls-concept:C1519941
pubmed:issue	Pt 2
pubmed:dateCreated	2009-1-27
pubmed:abstractText	Although many factors influence the quality of a macromolecular crystal structure, validation criteria are usually only calibrated using one of these factors, the resolution. For many purposes this is sufficient, but there are times when one wishes to compare one set of structures with another and the comparison may be invalidated by systematic differences between the sets in factors other than resolution. This problem can be circumvented by borrowing from medicine the idea of the case-matched control: each structure of interest is matched with a control structure that has similar values for all relevant factors considered in this study. In addition to resolution, these include the size of the structure (as measured by the volume of the asymmetric unit) and the year of deposition. This approach has been applied to address two questions: whether structures from structural genomics efforts reach the same level of quality as structures from traditional sources and whether the impact factor of the journal in which a structure is published correlates with structure quality. In both cases, once factors influencing quality have been controlled in the comparison, there is little evidence for a systematic difference in quality.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/050211
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-10713511, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-11937051, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-15130928, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-15572777, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-15965733, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-17452350, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-17704562, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-18617015, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-19171968, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-19171973, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-8692262, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-8994966, http://linkedlifedata.com/resource/pubmed/commentcorrection/19171969-9438862
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9305878
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1399-0047
pubmed:author	pubmed-author:KleywegtGerard JGJ, pubmed-author:ReadRandy JRJ
pubmed:issnType	Electronic
pubmed:volume	65
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	140-7
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:19171969-Computational Biology, pubmed-meshheading:19171969-Crystallography, X-Ray, pubmed-meshheading:19171969-Journal Impact Factor, pubmed-meshheading:19171969-Models, Molecular, pubmed-meshheading:19171969-Protein Conformation
pubmed:year	2009
pubmed:articleTitle	Case-controlled structure validation.
pubmed:affiliation	Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, England. rjr27@cam.ac.uk
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't