Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-27
pubmed:abstractText
In previous studies the cerebellar interpositus (IP) nucleus, but not the hippocampus, was shown to be necessary both for initial learning and retention and for long-term retention of the standard delay eyeblink conditioned response (CR). However, in the trace eyeblink CR procedure, the hippocampus is also necessary for initial learning and retention, but not for long-term retention. Here the authors evaluate the role of the IP nucleus in both initial learning and retention, and in long-term retention of the trace eyeblink CR, using muscimol infusion to reversibly inactivate the IP nucleus. For the short-term study, there were two subgroups, the first sequentially passed through acquisition, inactivation, and reacquisition phases, whereas the second subgroup went through inactivation, acquisition, and inactivation phases. For the long-term study, the rabbits acquired the CR and then rested for a month. Next, they were distributed into two subgroups: with or without retention training, and finally went through inactivation and reacquisition phases. The results showed that the prelearning IP nucleus inactivation prevented the acquisition of the trace CR, whereas the postlearning inactivation reversibly abolished the expression of both the short- and long-term CR.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-10456116, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-10832787, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-10884335, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-11142638, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-11285022, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-11403688, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-11588603, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-11722613, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-11726240, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-11726247, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-11770054, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-12713647, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-12750412, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-14586019, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-14657256, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-15708630, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-15839799, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-15912580, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-1616617, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-16719687, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-16928872, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-17046292, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-17224240, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-17551096, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-18199490, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-2346619, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-2590676, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-2765164, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-3237801, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-3778636, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-3814342, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-4075084, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-638791, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-6697177, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-7619310, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-7691076, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-8269040, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-8493536, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-8731049, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-9525860, http://linkedlifedata.com/resource/pubmed/commentcorrection/19170430-9588477
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0735-7044
pubmed:author
pubmed:copyrightInfo
(c) 2009 APA, all rights reserved.
pubmed:issnType
Print
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
54-61
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The role of the cerebellar interpositus nucleus in short and long term memory for trace eyeblink conditioning.
pubmed:affiliation
Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520, USA. pakaprot@usc.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural