Linked Life Data

1917025

Source:http://linkedlifedata.com/resource/pubmed/id/1917025

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-11-21
pubmed:abstractText
M cells are structurally distinctive, uniquely permeable epithelial cells found only overlying the domes of mucosal lymphoid follicles. Antigenic macromolecules and some viruses, bacteria, and protozoa enter their apical surface by endocytosis or phagocytosis. These substances traverse the M-cell cytoplasm by transcytosis, breaching the epithelial barrier, and then interact with the subepithelial immunocompetent cells to initiate mucosal and systemic immune responses. The M cell serves as a portal of entry for selected pathogens that cause disease locally in the wall of the intestine or, following dissemination, at distant sites. The mechanisms that regulate adherence to and penetration of M cells by macromolecules and microorganisms are not known, but selective binding of secretory IgA to the luminal surface may be important. Whether M cells simply serve a sieving function and always transport substances unchanged across the epithelial barrier or whether they also sort and process antigens they endocytose and present them to adjacent lymphoid cells requires further study.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0889-8553
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
531-47
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Structure and function of intestinal M cells.
pubmed:affiliation
Harvard Medical School, Boston, Massachusetts.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review