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19169270
Source:
http://linkedlifedata.com/resource/pubmed/id/19169270
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0020205
,
umls-concept:C0220781
,
umls-concept:C0243077
,
umls-concept:C1454853
,
umls-concept:C1880355
,
umls-concept:C1883254
pubmed:issue
2
pubmed:dateCreated
2009-2-5
pubmed:abstractText
The aim of this study was to design and synthesize a series of high activity compounds against aspartyl protease beta-secretase (BACE-1) bearing hydroxyethylene (HE) framework.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/100956087
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amides
,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases
,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid Endopeptidases
,
http://linkedlifedata.com/resource/pubmed/chemical/BACE1 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/GRL 7234
,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes
,
http://linkedlifedata.com/resource/pubmed/chemical/Phthalic Acids
,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides
,
http://linkedlifedata.com/resource/pubmed/chemical/Valine
,
http://linkedlifedata.com/resource/pubmed/chemical/isophthalate
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1745-7254
pubmed:author
pubmed-author:LiJing-YaJY
,
pubmed-author:MaLan-PingLP
,
pubmed-author:OsL OLO
,
pubmed-author:ShenJing-KangJK
,
pubmed-author:VigoC BCB
,
pubmed-author:WONGJJ
,
pubmed-author:XiongBingB
,
pubmed-author:YuHai-PingHP
,
pubmed-author:ZhangHai-YanHY
,
pubmed-author:ZhuYi-PingYP
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
259-69
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:19169270-Alzheimer Disease
,
pubmed-meshheading:19169270-Amides
,
pubmed-meshheading:19169270-Amyloid Precursor Protein Secretases
,
pubmed-meshheading:19169270-Animals
,
pubmed-meshheading:19169270-Aspartic Acid Endopeptidases
,
pubmed-meshheading:19169270-Computer Simulation
,
pubmed-meshheading:19169270-Drug Design
,
pubmed-meshheading:19169270-Humans
,
pubmed-meshheading:19169270-Isoenzymes
,
pubmed-meshheading:19169270-Models, Molecular
,
pubmed-meshheading:19169270-Molecular Structure
,
pubmed-meshheading:19169270-Phthalic Acids
,
pubmed-meshheading:19169270-Protease Inhibitors
,
pubmed-meshheading:19169270-Protein Conformation
,
pubmed-meshheading:19169270-Structure-Activity Relationship
,
pubmed-meshheading:19169270-Sulfonamides
,
pubmed-meshheading:19169270-Valine
pubmed:year
2009
pubmed:articleTitle
Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids.
pubmed:affiliation
The State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
pubmed:publicationType
Journal Article
,
Research Support, Non-U.S. Gov't