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rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-26
pubmed:abstractText
Commercial benzoic acid and salicylic acid ointments have been analyzed for benzoic acid and salicylic acid content by using a spectrophotometric method. Since benzoic acid and salicylic acid exhibit overlapping spectra, absorbance measurements are made at two wavelengths, i.e. 271 nm and 303 nm in ethanol (96%v/v) for simultaneous determination of the two compounds. The method is direct and involves only one step of absorbance measurement in the assay. The precision of the method, based on the analysis of synthetic mixtures of the two compounds, is within 2%. The recoveries of benzoic acid and salicylic acid in the ointments range from 99.9 to 100.6% and 99.5 to 101.3%, respectively and are comparable with those of the USP method (99.8 to 100.5% and 100.2 to 101.7%, respectively). The proposed method is simple, rapid, precise and convenient for the assay of benzoic acid and salicylic acid in commercial preparations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1011-601X
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-22
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Determination of benzoic acid and salicylic acid in commercial benzoic and salicylic acids ointments by spectrophotometric method.
pubmed:affiliation
Dubai Pharmacy College, Dubai, United Arab Emirates.
pubmed:publicationType
Journal Article