Linked Life Data

19168395

Source:http://linkedlifedata.com/resource/pubmed/id/19168395

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Suppl
pubmed:dateCreated
2009-3-2
pubmed:abstractText
The mechanisms underlying sudden cardiac death (SCD) are complex and diverse. Therefore, correct application of any marker to risk stratify patients for appropriate therapy requires knowledge regarding how the marker is reflective of a particular electroanatomical substrate for arrhythmias. Noninvasive measurement of beat-to-beat alternation of the electrocardiographic T-wave, referred to as T-wave alternans (TWA), is an important marker of risk for SCD. Is this relationship a mere association, or is TWA mechanistically linked to SCD? Recent experimental evidence strongly supports a mechanistic relationship between TWA and SCD. This review considers the underlying mechanisms of TWA derived from experimental studies, as they relate to clinical observations of TWA in humans, addressing the following questions derived from common clinical observations: (1) Where does TWA on the surface electrocardiogram come from? (2) Why is controlled heart rate elevation required to elicit TWA? (3) Why is TWA associated with risk for SCD? (4) Why is TWA associated with a broad range of ventricular arrhythmias? (5) How do commonly used medications affect TWA?
pubmed:grant
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1556-3871
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S22-8
pubmed:dateRevised
2010-9-23
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Explaining the clinical manifestations of T wave alternans in patients at risk for sudden cardiac death.
pubmed:affiliation
Heart and Vascular Research Center and Department Biomedical Engineering, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109-1998, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural