rdf:type |
|
lifeskim:mentions |
umls-concept:C0017638,
umls-concept:C0018017,
umls-concept:C0034897,
umls-concept:C0123931,
umls-concept:C0796392,
umls-concept:C0871261,
umls-concept:C1571702,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1719797,
umls-concept:C2911648,
umls-concept:C2911692
|
pubmed:issue |
7
|
pubmed:dateCreated |
2009-4-13
|
pubmed:abstractText |
Chemotherapy has taken on a prominent role in the treatment of pediatric low-grade gliomas not amenable to gross total resections; however, there are few proven effective options for children with multiply recurrent tumors. Bevacizumab, a humanized immunoglobulin, monoclonal antibody that inhibits the activity of vascular endothelial growth factor and irinotecan have been used with some success in adults with malignant gliomas.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
1545-5017
|
pubmed:author |
|
pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
52
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
791-5
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:19165892-Antibodies, Monoclonal,
pubmed-meshheading:19165892-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:19165892-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19165892-Brain Neoplasms,
pubmed-meshheading:19165892-Camptothecin,
pubmed-meshheading:19165892-Child,
pubmed-meshheading:19165892-Child, Preschool,
pubmed-meshheading:19165892-Glioma,
pubmed-meshheading:19165892-Humans,
pubmed-meshheading:19165892-Infant,
pubmed-meshheading:19165892-Maximum Tolerated Dose,
pubmed-meshheading:19165892-Neoplasm Recurrence, Local,
pubmed-meshheading:19165892-Prospective Studies,
pubmed-meshheading:19165892-Treatment Outcome
|
pubmed:year |
2009
|
pubmed:articleTitle |
Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan.
|
pubmed:affiliation |
Division of Neurology, Children's National Medical Center, Washington, District of Columbia 20010, USA. rpacker@cnmc.org
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|