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rdf:type |
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lifeskim:mentions |
umls-concept:C0002940,
umls-concept:C0013935,
umls-concept:C0017262,
umls-concept:C0024375,
umls-concept:C0026844,
umls-concept:C0037083,
umls-concept:C0040690,
umls-concept:C0181586,
umls-concept:C0185117,
umls-concept:C0221099,
umls-concept:C0332197,
umls-concept:C0392756,
umls-concept:C1710082,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2009-3-2
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pubmed:abstractText |
To address the requirement for TGFbeta signaling in the formation and maintenance of the vascular matrix, we employed lineage-specific mutation of the type II TGFbeta receptor gene (Tgfbr2) in vascular smooth muscle precursors in mice. In both neural crest- and mesoderm-derived smooth muscle, absence of TGFbeta receptor function resulted in a poorly organized vascular elastic matrix in late-stage embryos which was prone to dilation and aneurysm. This defect represents a failure to initiate formation of the elastic matrix, rather than a failure to maintain a preexisting matrix. In mutant tissue, lysyl oxidase expression was substantially reduced, which may contribute to the observed pathology.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Mmp9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Lysine 6-Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/transforming growth factor-beta...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1526-968X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-21
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pubmed:meshHeading |
pubmed-meshheading:19165826-Aneurysm,
pubmed-meshheading:19165826-Animals,
pubmed-meshheading:19165826-Base Sequence,
pubmed-meshheading:19165826-DNA Primers,
pubmed-meshheading:19165826-Elastic Tissue,
pubmed-meshheading:19165826-Female,
pubmed-meshheading:19165826-Gene Expression Regulation, Developmental,
pubmed-meshheading:19165826-Matrix Metalloproteinase 9,
pubmed-meshheading:19165826-Mice,
pubmed-meshheading:19165826-Mice, Mutant Strains,
pubmed-meshheading:19165826-Mice, Transgenic,
pubmed-meshheading:19165826-Muscle, Smooth, Vascular,
pubmed-meshheading:19165826-Mutation,
pubmed-meshheading:19165826-Pregnancy,
pubmed-meshheading:19165826-Protein-Lysine 6-Oxidase,
pubmed-meshheading:19165826-Protein-Serine-Threonine Kinases,
pubmed-meshheading:19165826-RNA,
pubmed-meshheading:19165826-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:19165826-Signal Transduction,
pubmed-meshheading:19165826-Tissue Distribution,
pubmed-meshheading:19165826-Transforming Growth Factor beta
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pubmed:year |
2009
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pubmed:articleTitle |
Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm.
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pubmed:publicationType |
Letter,
Research Support, N.I.H., Extramural
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