rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-29
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pubmed:abstractText |
Radiolabeled arginine-glycine-aspartate (RGD) peptides are increasingly used in preclinical and clinical studies to assess the expression and function of the alphavbeta3 integrin, a cellular adhesion molecule involved in angiogenesis and tumor metastasis formation. To better understand the PET signal obtained with radiolabeled RGD peptides, we have constructed a compartmental model that can describe the time-activity curves in tumors after an intravenous injection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,4,7,10-tetraazacyclododecane-...,
http://linkedlifedata.com/resource/pubmed/chemical/Copper Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Heterocyclic Compounds, 1-Ring,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alphaVbeta3,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Radiopharmaceuticals,
http://linkedlifedata.com/resource/pubmed/chemical/arginyl-glycyl-aspartic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
250-8
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pubmed:meshHeading |
pubmed-meshheading:19164244-Animals,
pubmed-meshheading:19164244-Cell Line, Tumor,
pubmed-meshheading:19164244-Copper Radioisotopes,
pubmed-meshheading:19164244-Heterocyclic Compounds, 1-Ring,
pubmed-meshheading:19164244-Humans,
pubmed-meshheading:19164244-Integrin alphaVbeta3,
pubmed-meshheading:19164244-Male,
pubmed-meshheading:19164244-Mice,
pubmed-meshheading:19164244-Mice, SCID,
pubmed-meshheading:19164244-Models, Biological,
pubmed-meshheading:19164244-Neoplasm Transplantation,
pubmed-meshheading:19164244-Neoplasms, Experimental,
pubmed-meshheading:19164244-Oligopeptides,
pubmed-meshheading:19164244-Positron-Emission Tomography,
pubmed-meshheading:19164244-Radiopharmaceuticals,
pubmed-meshheading:19164244-Tomography, X-Ray Computed
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pubmed:year |
2009
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pubmed:articleTitle |
Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice.
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pubmed:affiliation |
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095-6948, USA. gzferl@ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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