Linked Life Data

19162613

Source:http://linkedlifedata.com/resource/pubmed/id/19162613

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-2-16
pubmed:abstractText
Regional differences in electrical action potential (AP) properties can provide a substrate for atrial arrhythmias. We quantify such differences by developing detailed AP models for the left (LA) and right (RA) rabbit atrial cells in order to study the underlying electrophysiological mechanisms, as well as their impacts on vulnerable properties of the atrial tissue. The transient outward current, Ito, is identified as the major factor contributing to the AP differences between the LA and RA cells, which suggests a potential pharmacological target for reducing heterogeneity and vulnerability of the atria.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1557-170X
pubmed:author
pubmed:issnType
Print
pubmed:volume
2008
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-4
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Regional differences in rabbit atrial action potential properties: mechanisms, consequences and pharmacological implications.
pubmed:affiliation
School of Physics and Astronomy, University of Manchester, Manchester, M13 9PL, United Kingdom. oleg.aslanidi@manchester.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't