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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-2-16
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pubmed:abstractText |
The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-10898161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-11041540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-11170252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-11640919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-12036344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-14654093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-15018832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-1684903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-1975272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-7500277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-7644474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-7815345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-7911064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-7915948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-8103555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-8117384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-8421494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-8930991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-9192690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-9685234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19162477-9746904
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1254-7
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pubmed:dateRevised |
2010-9-22
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pubmed:meshHeading |
pubmed-meshheading:19162477-Administration, Oral,
pubmed-meshheading:19162477-Animals,
pubmed-meshheading:19162477-Benzothiadiazines,
pubmed-meshheading:19162477-Combinatorial Chemistry Techniques,
pubmed-meshheading:19162477-Hippocampus,
pubmed-meshheading:19162477-Models, Molecular,
pubmed-meshheading:19162477-Molecular Structure,
pubmed-meshheading:19162477-Rats,
pubmed-meshheading:19162477-Receptors, AMPA,
pubmed-meshheading:19162477-Receptors, Kainic Acid,
pubmed-meshheading:19162477-Sulfonamides
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pubmed:year |
2009
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pubmed:articleTitle |
A novel class of allosteric modulators of AMPA/Kainate receptors.
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pubmed:affiliation |
Department of Pharmaceutical Science, University of Modena e Reggio Emilia, Via Campi 183, 41100 Modena, Italy. giuseppe.cannazza@unimo.it
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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